The pharmacological properties of the Ca-induced Ca release mechanism and its role in Ca mobilization
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Suramin and Disulfonated Stilbene Derivatives Stimulate the Ca -Induced Ca -Release Mechanism in A7r5 Cells
We have described previously a novel Ca -induced Ca release (CICR) mechanism in permeabilized A7r5 cells (embryonic rat aorta) and 16HBE14ocells (human bronchial mucosa) cells (J Biol Chem 278:27548–27555, 2003). This CICR mechanism was activated upon the elevation of the free cytosolic calcium concentration [Ca ]c and was not inhibited by pharmacological inhibitors of the inositol-1,4,5-trisph...
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از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...
15 صفحه اولLuminal Ca Controls Termination and Refractory Behavior of Ca -Induced Ca Release in Cardiac Myocytes
Despite extensive research, the mechanisms responsible for the graded nature and early termination of Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) in cardiac muscle remain poorly understood. Suggested mechanisms include cytosolic Ca -dependent inactivation/adaptation and luminal Ca -dependent deactivtion of the SR Ca release channels/ryanodine receptors (RyRs). To explore ...
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Fellner SK, Arendshorst WJ. Voltage-gated Ca entry and ryanodine receptor Ca -induced Ca release in preglomerular arterioles. Am J Physiol Renal Physiol 292: F1568–F1572, 2007. First published December 26, 2006; doi:10.1152/ajprenal.00459.2006.—We have previously shown that in afferent arterioles, angiotensin II (ANG II) involves activation of the inositol trisphosphate receptor (IP3R), activat...
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Ca is a multifunctional signaling messenger crucial for diverse biological processes. Among the various ways by which cellular Ca signals are generated, storeoperated Ca release-activated Ca (CRAC) channels are recognized as a widespread mechanism for regulating transcription, motility, and proliferation in many cells (Feske, 2009; Hogan et al., 2010; Lewis, 2011). CRAC channels produce sustain...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58893-x